This is what my default template contains (for a TI keyboard):
Virus TI - set to 3 in / 1 out. Surround set also to USB 1 L+R (just because I sometimes stick different fx chains on 1 and 2 and the surround fader letsme crossfade between chains)
Track 1 - MIDI track with Virus TI VC plugin - this get default midi in and default audio out (USB 1 L+R). I have explicitly set USB 1 L+R on the Patch for part 1.
Track 2 - MIDI track with external instrument plugin - MIDI to Virus TI, ch.2, audio from Virus TI 2 (which is USB 2 L+R). I set TI part 2 to USB 2 L+R.
Track 3 - MIDI track with external instrument plugin - MIDI to Virus TI, ch.3, audio from Virus TI 3 (which is USB 3 L+R) with Utility plugin to select L channel only, the TI part in VC is set to USB 3 L
Track 4 - MIDI track with external instrument plugin - MIDI to Virus TI, ch.3, audio from Virus TI 3 (which is USB 3 L+R) with Utility plugin to select R channel only, the TI part in VC is set to USB 3 R.
With this template, I can also just send audio to the Virus TI midi channel, with the result it goes to the Virus TI USB inputs, and then comes out of whichever part outputs the input patch(es) is/are using.
This basically gives me 4 fairly indpendent synths, two stereo, and two mono, of which one can serve as an stereo fx processor and also accept full automation, whereas the others can only be controlled via midi (unless they have their automation on the VC plugin channel). TBH - thats about the best I usually get out the TI in terms of poly for the part complexities I have anyway.
I had wanted to setup another few channels using the external instrument plugin to get compensated audio from the analog outs as well, however Lives external instrument plugin doesnt support routing midi to a plugin, then getting audio from an audio interface (I cant see why they didnt dod this - there are after quite a few hardware synth plugins around - Grrrr!!!

) - Shame - could have coaxed 6 or more independent synths out of it had that worked.