I'm having the same issues (sort of, but seems related) - in Live 10, on PC only.
If I load devices like Envelope Follower or LFO, Live is unresponsive between 10 and 30 seconds before it reacts again. I can sometimes move knobs a little bit before it stops working again.
It was not always like this, but since I move a lot between Mac - where this is not an issue - and PC, I can't really pinpoint when it started bugging out.
I've tried enabling and disabling HiDPI mode, I've tried the
options.txt trick as suggested here, nothing seems to work consistently. I've also updated the display drivers, checked on different monitor setups - but I just have one card in the PC (NVIDIA 1080TI), so been unable to check any compatability issues.
It's 100% sure that it's the graphical updates in the M4L windows that is the issue. Whenever I manage to close the plugin windows, ie hide the LFOs etc, Live is responsive again.
I'm sure this is not unique, but it's hard to search for as the bug is so strage and hard to describe. I'll dive more into this and also follow up the official support channels, and try to update in the forums if I get anywhere.