My system: mid-2012 MBP 2.3GHZ i7, 512SSD, 16GB RAM; running at 128 and CPU hovers between 30-50%.
I'm playing clips, live guitar and synth guitar. I have 12 instruments (some Ableton, some not) on a chain selector which I've mapped to 12 buttons on a midi controller. Patches are set to turn on and off, so only one instrument is turned on at a time.
The midi controller I'm using to control the chain selector is a KMI K-Mix, and it's settings are set to Track & Remote on Input and Output.
Would be thankful for advice. Let me know if I can provide more info. I really need to figure this out, obviously!!!