Well you have 2 long term users above you here that state no issues at all and both run Windows 10 so I would say it is more your setup.Might be my luck, but the fact that this works fine in a Mac and not in Windows just tells me the support in Windows is not as great.
You may have something that needs a tweak in your BIOS. AMD processors may not "just work" with every configuration in the same way Intel processors do. Mark above seems to be using AMD so it's not the architecture specifically but since you have it working on a Mac fine, the issue is not Push or Live nor is it a Windows issue. So right there you need to rule all these things out and not just assume because you have an issue on one OS that it must be an overall failing of support for it.
There may be some things between your CPU and MOBO that need tweaks, you may need updated GPU drivers, chipset, check your MOBO manufacturer website since you may have some generic drivers running for things like USB or chipset which would be better having the manufacturer ones.
Loads of things it could be including some apps you may have running but you are not aware of. Unload everything you can find from memory, try use a different audio driver, especially check your GPU drivers are up to date and maybe as a test remove that twitch card thing since that is something I don't have nor Mark I guess and maybe it causes an issue with Live.